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Glycosidation of 20(S)-protopanaxadiol obtained by the alkaline hydrolysis of total ginsenosides with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide in the presence of CdCO3 in benzene-dioxane gave a mixture of acetylated monoglucosides and diglucosides in a total yield of 68%. Under the same condenstion condition, 20-dehydroxyglucosides were formed by dehydration of 12-O-glucosides. The structures of produced glycosides were elucidated as 3-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, 12-O-beta-D-glucopyranosyl-dammar-20(22), 24-dien-3beta,12 beta-diol, 3,12-di-O-beta-D-glucopyranosyl-dammar-20(22), 24-dien-3beta, 12beta-diol, respectively.
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